Laryngeal tumours: clinical features and management challenges as seen in two centres in Port Harcourt, Nigeria
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Abstract
Background: Laryngeal tumours especially the malignant varieties are not uncommon with a number of factors affecting their management in most resource poor countries. Late clinical presentation and diagnosis is commonplace in the sub-Saharan region of Africa.
Aim: To determine the prevalence of laryngeal tumours as seen in two centres in Port Harcourt, Nigeria and highlights the challenges encountered in the management of these patients.
Methods: A retrospective study carried out using records of patients who presented with features of laryngeal tumours to both the University of Port Harcourt Teaching Hospital (UPTH) and Kinx Medical Consultants Hospital in Port Harcourt, Nigeria. The period of the study was from January 2003 to December 2014. Data extracted included age, gender, clinical features, radiological investigations, histopathologic diagnosis and treatment modalities. Data were analyzed using simple descriptive statistical methods.
Results: A total of thirty five cases were seen with laryngeal diseases during the 12-year period out of 2,300 patients who presented with laryngea symptoms giving a prevalence of 1.52%. There were 30 males and 5 females giving a male to female ratio of 6: 1. The age range was 40 years to 70 years. The mean age was 58.5 ± 4.55 years. The age range 50-59 years was mostly affected. The commonest mode of presentation was hoarseness (100%). Twenty five cases (71.43%) were found to be malignant diseases while 10 (28.57%) cases were benign diseases. Twenty (57.14%) of the patients had emergency tracheostomy. The predominant histological type was well differentiated squamous cell carcinoma [15(42.86%)]. Only three (8.57 %) patients had total laryngectomy.
Conclusion: The prevalence of laryngeal tumours in our environment was found to be 1.52% and patients within the middle age group were mostly affected. Well differentiated squamous cell carcinoma was the commonest histopathological type.
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References
1. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin 1999; 49: 33-64.
2. Mastronikolis NS, Papadas TA, Goumas PD, Triantaphyllidou IE, Theocharis DA, Papageorgakopoulou N, Vynios DH. Head and neck: Laryngeal tumours: an overview. Atlas Genet Cytogenet Oncol Haematol 2009; 13: 888-893.
3. Rothman KJ, Cann CI, Flanders D, Fried MP. Epidemiology of laryngeal cancer. Epidemiol Rev 1980; 2: 195-209.
4. Tuyns AJ, Esteve J, Raymond L, Berrino F, Benhamou E, Blanchet F, Boffetta P, et al. Cancer of the larynx/ hypopharynx, tobacco and alcohol: IARC International case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer 1988; 41: 483-491.
5. Mattlin C, Graham S, Priore R, Marshall J, Swanson M. Diet and cancer of the esophagus. Nutr Cancer 1981; 2: 143-147.
6. Koufman JA, Burke AJ. The etiology and pathogenesis of laryngeal cancinoma. Otolaryngol Clin North Am 1997; 30: 1-19.
7. Brandsma JL, Steinberg BM, Abramson AL, Winkler B. Presence of human papillomavirus type 16 related sequences in verrucous carcinoma of the larynx. Cancer Res 1986; 46 (4Pt 2): 2185-2188.
8. Doloi PK, Khanna S. A study of management of benign lesions of the larynx. International Journal of Phonosurgery and Laryngology 2011; 1:61-64.
9. Mastronikolis NS, Papadas TA, Goumas PD, Triantaphyllidou IE, Theocharis DA, Papageorgakopoulou N, Vynios DH. Tumours of the larynx. In: Watkinson JC, Gaze MN, Wilson JA Eds. Stell & Maran's Head and Neck Surgery, 4 t h edition. Oxford: Butterworth-Heinemann, 2000: 233-274.
10. Concus AP. Malignant laryngeal lesions. In: Lalwani AK, ed. Current diagnosis and treatment in Otolaryngology-Head and Neck Surgery. New York : Lange medical books/McGraw-Hill: 2004: 455-473.
11. Gan X, Zhou Y, Cai L. [Prognosis of laryngeal carcinoma in youth]. Zhonghua Er Bi Yan Hou Ke Za Zhi 1996; 31: 201-202.
12. Adoga AS, Ma'an EN. The challenges of treating laryngeal carcinoma in Jos Nigeria. J West Afr Coll Surg 2011; 1: 63-75.
13. Adeyemo AA, Mohammed GM. Laryngeal cancinoma in subSaharan Africa. J Clin Oncol 2008; 26 (15 Suppl): 17022
14. Iseh KR, Abdullahi M, Aliyu D. Laryngeal tumours: clinical pattern in Sokoto, Nortwestern Nigeria. Niger J Med 2011; 20: 75-82.
15. Umana A, Offiong M, Mgbe R, Adekanye A, Bassey I, Ebughe G. Cancer of the larynx- management challenges in Calabar, south- south Nigeria. The Internet Journal of Third World Medicine 2010; 9 (2).