Prevalence of tuberculosis‑HIV co‑infection and factors associated with treatment outcome among the tuberculosis patients in HIV treatment facility in a teaching hospital in Jos, North Central Nigeria

Main Article Content

Sunday Asuke
John Bimba
Swem Micheal Ngutor
Eunice Ejiga
Shanabo Z. Miracle
Dorcas M. Anamayi

Abstract

Background: Globally, tuberculosis (TB) remains a disease of grave public health concern. It ranks above HIV/AIDS as the leading cause of death from a single infectious agent, and as one of the 10 most common causes of mortality. This study assessed the prevalence of TB-HIV co-infection and factors associated with treatment outcome among the TB patients in an HIV treatment facility in a Teaching hospital in Jos, North central Nigeria.


Methods: A 10-year retrospective, descriptive cross-sectional review was conducted and data was extracted through the review of TB registers. Data were analysed using SPSS version 20 and bivariate analyses was conducted at P < 0.05.


Results: The prevalence of TB-HIV co-infection was 9.25%, with the mean age of the study participants being 41.8 ± 11.6 years. Of all the participants, 87.5% had successful treatment outcome, while 12.5% had unsuccessful treatment outcome. In the bivariate analysis, place of residence was the only socio-demographic factor significantly associated with treatment outcome (˂0.001).


Conclusion: The TB-HIV co-infection prevalence rate was about 10% of the total HIV population with a high TB treatment success rate. With the exception of place of residence, no other factor had statistically significant relationship with the treatment outcome.

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How to Cite
Prevalence of tuberculosis‑HIV co‑infection and factors associated with treatment outcome among the tuberculosis patients in HIV treatment facility in a teaching hospital in Jos, North Central Nigeria. (2020). Port Harcourt Medical Journal, 14(3), 119-124. https://doi.org/10.60787/phmj.v14i3.157
Section
Original Articles
Author Biography

Dorcas M. Anamayi, Department of Community Medicine and Primary Health Care, College of Medicine and Health Sciences, Jos Campus, Bingham University, New Karu, Nasarawa State, Nigeria



References

1. World Health Organization. Global Tb Report 2018. World Health Organization. Available from: http://www.who.int/tb/publications/global_report/en. [Last accessed on 2019 Jun 20].

2. Federal Ministry of Health. Nigeria STOP TB Partnership Strategic Plan 2013‑2015; 2013. Available from: http://www.stoptb.org/assets/documents/countries/partnership/Final%20. [Last accessed on 2020 Mar 24].

3. World Health Organization. The Global Plan to stop TB 2011–2015: Transforming the Fight Towards Elimination of Tuberculosis – Reprinted with Changes, 2011. World Health Organization; 2011. Available from: http://www.stoptb.org/assets/documents/global/plan/tb_globalplantostoptb2011‑2015.pdf. [Last accessed on 2019 Jun 20].

4. United States Embassy in Nigeria. Nigeria Tuberculosis Fact Sheet, 2012. Abuja, Nigeria; 2012. Available from: http://www.photos.state.gov/libraries/nigeria/487468/pdfs/JanuaryTuberculosisFactSheet.pdf. [Last accessed 2019 Oct 03].

5. Nigerian HIV/AIDS indicator and Impact Survey (NAIIS). National Agency for the Control of HIV/AIDS; 2018. Available from: https://www.naiis.ng/resource/factsheet/NAIIS PA. [Last acessed on 2020 Mar 23].

6. Federal Ministry of Health Nigeria. 2014 National Tuberculosis, Leprosy and Buruli ulcer Management and Control Guidelines (NTBLCP)

Annual Report. Available from: http://www.health.gov.ng/doc/NTBLCP%202014%20Annual%20report‑2.pdf. [Last accessed on 2019 Jun 15].

7. World Health Organization. WHO Policy on Collaborative TB/HIV activities: Guidelines for National Programmes and Other Stakeholders.

Geneva: World Health Organization; 2012. Available from: http://www.who.int/tb/publications/2012/tb_hiv_policy_9789241503006/en/. [Last accessed on 2019 Jul 15].

8. Daniel OJ, Alausa OK. Treatment outcome of TB/HIV positive and TB/HIV negative patients on directly observed treatment, short course (DOTS) in Sagamu, Nigeria. Niger J Med 2006;15:222‑6.

9. Ofoegbu OS, Odume BB. Treatment outcome of tuberculosis patients at National Hospital Abuja Nigeria: A five year retrospective study. S Afr Fam Pract 2015;57:1, 50‑6.

10. Tweya H, Feldacker C, Phiri S, Ben‑Smith A, Fenner L, Jahn A, et al. Comparison of treatment outcomes of new smear‑positive pulmonary

tuberculosis patients by HIV and antiretroviral status in a TB/HIV clinic, Malawi. PLoS One 2013;8:e56248.

11. Tabarsi P, Chitsaz E, Moradi A, Baghaei P, Marjani M, Mansouri D. Treatment outcome and mortality: Their predictors among HIV/TB

co‑infected patients from Iran. Int J Mycobacteriol 2012;1:82‑6.

12. World Health Organization. Definitions and Reporting Framework for Tuberculosis‑2013 Revision. Geneva, Switzerland: World Health

Organization; 2013. Available from: http://apps.who.int/iris/bitstream/10665/79199/1/9789241505345_eng.pdf [19] [Last accessed on 2019 Mar 10].

13. Ebuenyi ID, Ikuabe OP, Jumbo J. Treatment outcome of tuberculosis at one year: A single centre’s experience in Niger Delta, Nigeria. Int J

Trop Dis Health 2016;12:1‑6.

14. Oshi DC, Oshi SN, Alobu I, Ukwaja KN. Profile, outcomes, and determinants of unsuccessful tuberculosis treatment outcomes among HIV‑infected tuberculosis patients in a Nigerian State. Tuberc Res Treat 2014;2014:202983.

15. Duru CB, Uwakwe KA, Nnebue CC, Diwe KC, Merenu IA, Emerole CO, et al. Tuberculosis treatment outcomes and determinants among patients treated in hospitals in Imo State. Nigeria 2016;3:1‑17.

16. Fatiregun AA, Ojo AS, Bamgboye AE. Treatment outcomes among pulmonary tuberculosis patients at treatment centers in Ibadan, Nigeria.

Ann Afr Med 2009;8:100‑4.

17. Babatunde OA, Elegbede OE, Ayodele M, Fadare JO, Isinjaye AO. Factors affecting treatment outcomes of tuberculosis in a tertiary health center in Southwestern Nigeria. Int Rev Soc Sci Humanities 2013;4:209‑18.

18. Garedew D, Nemera G. Treatment outcome of tuberculosis and associated factors at gimbi town health facilities Western Oromia, Ethiopia. Nursing Care Open Access J 2017;7:38‑42.

19. Biruk M, Yimam B, Abrha H, Biruk S, Amdie FZ. Treatment outcomes of tuberculosis and associated factors in an Ethiopian University

hospital. Adv Public Health 2016; p.9.

20. Melese A, Zeleke B, Ewnete B. Treatment Outcome and Associated Factors among Tuberculosis Patients in Debre Tabor, Northwestern

Ethiopia: A Retrospective Study. Tuberc Res Treat 2016;2016:1354356; p.8.

21. Getahun B, Ameni G, Medhin G, Biadgilign S. Treatment outcome of tuberculosis patients under directly observed treatment in Addis Ababa, Ethiopia. Braz J Infect Dis 2013;17:521‑8.

22. Berhe G, Enquselassie F, Aseffa A. Treatment outcome of smear‑positive pulmonary tuberculosis patients in Tigray Region, Northern Ethiopia. BMC Public Health 2012;12:537.

23. Endris M, Moges F, Belyhun Y, Woldehana E, Esmael A, Unakal C. Treatment outcome of tuberculosis patients at enfraz health center,

northwest ethiopia: A five‑year retrospective study. Tuberc Res Treat 2014;2014:726193.

24. Sume GE, Hoshen M, Bita G, Kabore S, Nzima VN. Treatment outcome of TB/HIV positive and negative smear positive pulmonary

tuberculosis patients treated using daily self‑administered therapy in a Cameroonian district hospital. East Afr Med J 2009;86:469‑75.

25. Ukwaja KN, Oshi SN, Alobu I, Oshi DC. Profile and determinants of unsuccessful tuberculosis outcome in rural Nigeria: Implications for tuberculosis control. World J Methodol 2016;6:118‑25.

26. Ifebunandu NA, Ukwaja KN, Obi SN. Treatment outcome of HIV‑associated tuberculosis in a resource‑poor setting. Trop Doct 2012;42:74‑6.

27. Njepuome N, Odume B. The impact of HIV syndromes on the treatment of TB cases in Gombe State, Nigeria. Afr J Resp Med 2009;5:16‑20.

28. Patel AK, Thakrar SJ, Ghanchi FD. Clinical and laboratory profile of patients with TB/HIV coinfection: A case series of 50 patients. Lung India 2011;28:93‑6.

29. WHO, Global Tuberculosis Control: WHO Report 2019. Geneva, Switzerland: World Health Organisation; 2019. Available from: https://

www.who.int/tb/publications/global_report. [Last accessed on 2019 Feb 12].

30. Van don Boogaard J, Lyimo R, Irongo CF, Boeree MI, Scheaalma H, Aamoutse RE, et al. Community vs. facility based directly observed

treatment for tuberculosis in Tanzania’s Kilimanjaro Region. Int J Tuberc Lung Dis 2009;13:1524‑29.

31. Harries AD, Nyirenda TE, Baneiyee A, Boeree MI, Salaniponi FM. Treatment outcome of patients with smear negative and smear pulmonary tuberculosis in the National tuberculosis Control Program, Malawi. Trans R Soc Trop Med Hgy 1999;93:443‑46.

32. Thuy TT, Shah NS, Anh MH, Nghia do T, Thom D, Linh T, et al. HIV‑associated TB in An Giang Province, Vietnam, 2001‑2004: Epidemiology and TB treatment outcomes. PLoS One 2007;2:e507.

33. Tola A, Minshore KM, Ayele Y, Mekuria AN. Tuberculosis treatment outcomes and associated factors among TB patients attending public

hospitals in Harar Town, Eastern Ethiopia: A five‑year retrospective study. Tuberc Res Treat 2019;2019:1503219; p.11.